Another advantage is the fact that the created tool gives the opportunity for earlier use.
Because tumour angiogenesis occurs in a very early stage of carcinogenesis, there is a strong rationale for earlier use of bevacizumab in the adjuvant setting [ 83].
For the (not very important) recent mobile phone use, self reports seem to be fairly accurate, but for earlier use, no data on reliability are available.
Dipeptidyl peptidase-4 inhibitors are good candidates for early use as they are efficacious in combination with metformin, show weight neutrality and a low risk of hypoglycaemia.
For asthma and wheeze at 6 years, an association was obtained for use of paracetamol between 5 and 6 years of age (>19 times), but not for early use.
The population consisted of individuals who were late adopters of secure email use with clinicians and likely differed in systematic ways from those who opted for earlier use, which may limit the generalisability of the results.
The members we included in our study likely differed in systematic ways from those who opted for earlier use, but the potential impact of these differences on our findings is unknown.
This is probably a reflection of an increased trend for earlier use of O over I in 5-FU-pretreated metastatic CRC after the results of N9741, the Northern Central Cancer Treatment Group trial, had been reported.
Parchment is an important archival material, mostly used as support for writing and illuminations, as well as structural material (book binding, etc).. Historically, parchment was officially introduced in the city of Pergamum around the 2nd century A.D., although there is evidence for earlier uses [1, 2].
Shapiro sifted through the billions of words in JSTOR, an electronic journal archive, looking for the earliest use of "software".
See example (1) below for the earliest use of BREXIT that this author could find on Twitter, suggesting it was first used in a blog post.
