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Notably, Half DVD-Ig molecules that are monovalent for each specificity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.
The method we propose smoothes over any heterogeneity in the epitope-specific CTL response and provides an average efficiency of killing for each specificity.
A table is given showing motifs distinctive for each specificity as extracted from 316 sequences, which should aid in identifying the enzyme from primary structure information.
To test whether enrichment might be detectable, we ran computer simulations for each specificity.
A training collection for each specificity was assembled comprising 10 exposed and 10 unexposed sets.
We tested this approach for each specificity by seeing how well exposed and unexposed sets could be assigned.
Similar(44)
Again, for each SNP, specificity was measured as the number of discrepancies across samples (Figure 2, x axis).
The cutoff level (in arbitrary units) defining positivity for each ACPA specificity was determined on the basis of the 98th percentile of the values in 100 healthy controls.
In the case of Bayes ensemble model, a curve can be traced for each sensitivity-specificity combination obtained after changing the value of the cut-off.
Melting-curve analysis was performed for each gene for specificity of qPCR products.
For linear activation, deriving expressions for each of the specificity indicators has been done previously [ 25].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com