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The resulting data per drug was averaged for each regimen and used to make Fig. 3g and h.
For each ensemble of selected hypothetical drugs, we performed the best performing dose analysis and averaged the % HIV reactivation and % apoptosis for each regimen as above.
The International AIDS Society-USA genotypic resistance guidelines were used to calculate regimen resistance cost (RCreg) and number of active drug (AD) scores for each regimen and to rank the regimens.
If a patient took multiple regimens with the same drug count within a medication class, the PDD/DDD ratio for each regimen was weighted by the percent of days taken.
For each regimen, exercise-trained flies were compared to unexercised flies.
If a patient started more than one chemotherapy regimen during the 12 month period, the data were collected for each regimen because their weight and hence BSA might have changed.
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Table 1 Mean values and standard deviations of before and after CFU for each irrigation regimen Colony forming units Irrigation regimen Before After Conventional delivery 4.83 ± 0.39 1.42 ± 1* PIPS 4.92 ± 0.29 0.25 ± 0.45* *Statistical significant differences between groups.
Each regimen retails for $160 to $190 for a two-month supply and comes in a multistep process--including cleanser, toner and skin cream--much like Proactiv.
Patients were required to have previously received at most three chemotherapy regimens (at most two for advanced disease) with each regimen including an anthracycline or a taxane.
A 5,000 trial Monte Carlo simulation (Crystal Ball 2000, Decisioneering, Denver, CO, USA) was conducted for each antimicrobial regimen using the pharmacokinetic model in order to determine the regimen's probability of target attainment (PTA) profile.
Prior virologic failure doubled the risk of subsequent virologic failure in a cross-sectional study [17], and viral rebound rates were associated with the number of regimens previously failed, the risk increasing by 38% for each failed regimen [6].
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