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Consistent with a GD event in the grade IV region followed by chromosome losses due to increasing CIN [ 15], flow cytometry on the fresh tissue of the three recurrence samples revealed a DNA index of 1.60, 1.58 and 1.55 for each recurrence region (supplementary Figure S8, available at Annals of Oncology online).
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For each patient, recurrence-free survival (RFS) was defined as the time interval between the date of diagnosis to first recurrence (including local or regional recurrence and organs metastasis).
The calculated depths are the maximum water depths observed for each of the recurrence intervals indicated in the figure.
For each chromosome, a recurrence index (RI) was defined as the ratio of the number of affected cell lines and the total number of tested cell lines.
Relative risk (RR) and 95% confidence interval (CI) were calculated for each study for the recurrence rate and mortality rate among HT users and nonusers.
During each visit, brain MRI and chest radiography were performed in each patient for determining recurrence or metastasis.
The hazard rates for IBTR maintain the bimodal pattern for ERP and ERN tumours; however, each IBTR recurrence peak for ERP tumours is delayed in comparison to the corresponding timing of recurrence peaks for ERN tumours.
Finally, when soft discriminators for single-copy gain and for mono- and biallelic losses are combined across all tumors, they are a proxy for the recurrence of each alteration type.
Without parameter re-estimation, this model was then used to predict posterior probability representing the risk for tumor recurrence in each patient in two test sets (MSK and DFCI), as well as the censored cases left out of the model construction.
The frequency, site of first recurrence and the first salvage treatment modality for locoregional recurrence in each treatment group are summarized in Table 3.
Most importantly, we were able to show that LND was sensitive enough to identify a subpopulation of patients who are at high risk for tumour recurrence within each pN classification.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com