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For each dataset, the analysis was performed as follows (summarized in Figure S1): we have calculated a percentrank (pr) for each probe in each sample and each replicate.
Then, we have calculated a weighted percent rank (wpr) for each probe in each sample and each replicate, defined as the percentrank of this probe multiplied by its weight (wpr = pr *weight).
For analysis of gene expression patterns in the 64-sample set, the signal value for each probe in each sample was calculated as the log-transformed ratio of normalized intensity versus the background (common for all microarray data after normalization).
We then calculated the median of the normalized signal intensity for each probe in each sample, and used the resulting median signal intensity to represent the signal intensity of each probe.
A modified t-test is calculated from the three probes on either side of the segmentation point, using the median values of the three replicates for each probe in each sample.
Background corrected and RMA-normalized signal values for each probe in each sample were log2 transformed and median centered across 11 probes per sample.
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First, for each probe in a particular sample, we calculate a 'splicing index', represented as the background corrected probe intensity divided by the estimated gene expression index.
Relative copy number was calculated for each probe in reference to the unamplified DNA sample for each subject.
As this procedure removes data from all arrays for a particular probe, the sample sizes are the same for each probe in the final dataset.
The level of DNAm for 428,216 probes in our sample dataset was intersected with the expanded annotation for further analyses.
Response times for each C-probe annealing and each sample were scored for acceptance in the following sequence.
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for each probe in each order
for each probe in each sequence
for each allele in each sample
for each probe in each experiment
for each sncRNA in each sample
for each chromosome in each sample
for each miRNA in each sample
for each probe in each species
for each probe in each group
for each probe in each control
for each locus in each sample
for each probe in each tumour
for each probe in each array
for each probe in each overlap
for each gene in each sample
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