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Based on extensive reviews of the cancer hallmarks, this model selects multiple high-priority targets for each hallmark, to be approached with combinations of low-toxicity, low-cost therapeutics, including phytochemicals, adapted to the well-known complexity and heterogeneity of malignancy.
Fully referenced results for each hallmark area can be found in each of the individual reviews within this special issue.
It may also be productive to identify 'reference compounds' (ideal and prototypical disruptors) for each hallmark pathway as a guide to predict different combinations of chemicals that might act in a procarcinogenic manner on any one of the hallmarks.
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For each functional hallmark, each differentially regulated transcript is grouped into a distinctive pathway.
It's a made-for-Hallmark event, the sentimentality implicit.
It was a made-for-Hallmark moment, the championship trophy passing from one brother to another as if it were a family heirloom.
As for that hallmark trapezoid that Mr. Kriemler loves so much?
And that feature meshes beautifully with Mr. Jacobs's style, for a hallmark of his performances is driving energy.
True, the painting did not seem destined for a Hallmark card, would not have been mistaken for the work of Norman Rockwell.
Moreover, such ethical codes stand for the hallmark of the professional status (Barnett 2001).
Maybe it was her baggy sweatpants, maybe the sandals, maybe her tender years, but each of my friend's questions brought a sniff from the dealer that said perhaps you've mistaken us for a Hallmark card shop.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com