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Our observations led us to propose a model for distinct effects of ERK1 and ERK2 knockdown in developmental signaling processes, by effecting common as well as distinct genes (Fig. 2G).
In the case of non-proportionality (Schoenfeld residual global test p<0.05), we used a change-point estimate approach 21 22 to account for distinct effects on mortality at younger and older ages.
Since it is known that TFAP2 activity can be modulated by a wide range of interacting proteins [ 12], it is conceivable that differential expression and functional roles of TFAP2A co-factors may account for distinct effects on DCBLD2/ESDN gene transcription.
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Nonetheless, these results support our previous hypothesis of distinct effects for each of the treatments and further suggest the presence of an additional nutrient factor regulating the formation of H2S.
Detailed analysis about the effect of driving frequency on discharge characteristics is presented and two different dominant electron loss mechanisms, namely transport-dominated loss and diffusion-dominated loss, are proposed to account for the distinct effects of the driving frequency on argon discharge characteristics.
Furthermore, this model provides a formal explanation for the morphogenetic role of the initial bell-shaped expression of the gene even-skipped, i.e. for the distinct effects of different levels of the Even-skipped protein on its target pair-rule genes.
However, the reasons for the distinct effects of Res have been veiled yet.
We considered two explanations for the distinct effects of the tub var chromosomes in different in vivo contexts.
An alternative explanation for the distinct effects of ecr2-1 on ctr1-10 and ctr1-8 could arise from a role of ECR2 in CTR1 stability.
This temperature-dependent difference in the efficacy of carbachol in decreasing the initial release probability could account for its distinct effects on synaptic depression.
Altered balance of cell-proliferative PGE 2 and other endogenous anti-inflammatory prostanoids was suspected as the mechanism for the distinct effects of PGE 2 during recovery and the acute phase of colitis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com