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The hereditary blood vessel diseases of the skin, for example, many of which are under direct genetic control, sometimes do not become evident until the hormonal changes of puberty create conditions optimal for disease expression.
Such an interaction may have important implications for disease expression associated with HTLV-I infection.
Inherited autosomal recessively, either two copies of Hb S or one copy of Hb S plus another beta-globin variant (such as Hb C) are required for disease expression.
This is a good example of what lifestyle changes can do for disease expression.
In other words, a single common locus will contribute modestly to the disease risk and, thereby, require the simultaneous effects of other loci (i.e., polygenicity) for disease expression.
In addition, pathogens like D. dadantii may colonize their host asymptomatically and intensive multiplication and maceration symptoms only occur when environmental conditions are favourable for disease expression [15].
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To account for the specificity of disease expression, we suggest that incapacitation of only a fraction of the Ca2+ channels clustered at active zones would severely depress transmitter release.
Thus, Th17 cells are required for full disease expression in PPARβ/δ transgenic mice.
The frequencies of pathogenic variants will, on the other hand, be directly proportional to the extent of polygenicity required for individual disease expression.
Decreasing the infectious dose of RBC to 105 per mouse did not alter the phenotypic difference between the two mouse strains (data not shown), suggesting that parasitemia does not represent the critical parameter for accelerated disease expression and mortality in H3R−/− mice.
Using several polyarticular arthritis models, which all involve immune complexes and C5 activation [ 33, 34], we showed here that u-PA is important for full disease expression.
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