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Cytomegaloviruses (CMVs) can infect professional antigen presenting cells (APCs), including dendritic cells, thus providing peptides for direct presentation.
These results suggest that the cell types targeted in vivo by VRP carrying mutant or wild type glycoprotein spikes are functionally different, and are consistent with previous findings suggesting that wild-type VEE glycoproteins preferentially target professional antigen presenting cells that use peptides generated from the degraded antigen for direct presentation on MHC.
MCMV infects professional APCs, including dendritic cells in vivo [8], thus potentially providing antigen for direct presentation.
However, direct infection with the ΔgL virus, where infection of DCs for direct presentation can occur, elicited a response that is very similar to that elicited by ΔgL-infected fibroblasts, where only cross-presentation is possible.
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Many of these were patients whose pathway to diagnosis bypassed primary care, for example, through direct presentation to an emergency department.
Thus, the results do not unambiguously establish that LNSC are responsible for any increase in representation of Treg or Treg subsets via direct presentation of antigen.
Poetry offers the most direct presentation of "aesthetic ideas".
In November's first Nintendo Direct presentation without Iwata, that exact character was confirmed: the twin crossbow-wielding Linkle will be introduced in 2016's Hyrule Warriors Legends for 3DS.
These combined data suggest that antigen specific T cells can be primed via direct presentation and that cross-presentation may not necessarily be the primary mechanism for T cell activation in response to Lm in vivo.
The direct presentation of the diplotype configurations in conjunction with such LD information allows for the simultaneous inference of the underlying haplotype structures in a single display.
Bilateral amygdala activation (maximum at: MNI 24, −4, −20: Z = 2.28 and −22, −7, −18: Z = 2.36) was found for short duration averted versus direct presentations (Fig. 2a), in agreement with the signal changes reported by Hadjikhani et al. (2008) for the left amygdale and as reported for dynamic stimuli in (N'Diaye et al. 2009).
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