Immunohistochemistry for differentiated cell types, cell proliferation, apoptosis and β-catenin expression was completed using standard techniques (online supplementary methods and supplementary table 1).
Geum et al. reported that the disease-specific 5-year survival rate was 94.7 % for the well-differentiated type, 57.1 % for the moderately differentiated type, and 25.0 % for the poorly differentiated type related to survival rate of oral squamous cell carcinoma according to histopathological differentiation [22].
Gastric intestinal metaplasia (IM) is associated with a risk for development of differentiated-type gastric cancers.
But Liu et al. reported that overall 5-year survival rate was 77.3 % for the well-differentiated type and 76.7 % for the moderately differentiated type, which was not statistically significant [6].
For the majority of the poorly differentiated DCISs this may take less than 5 years, while for the well differentiated type it probably takes more than 10 15 years.
In the absence of T3, protein levels for PGC1α were similar for differentiated wild type and Fsp27−/− MEFs (Fig. 6D), which is in drastic contrast to the phenotypic changes seen between the wildtype and mutant adipocytes derive from the mice.
We have reported the clinical validity of ESD without additional surgical resection for SM1-GCs of the differentiated type that are <30 mm in diameter and without vessel involvement [ 8, 9] as well as the usefulness of ESD for EGC with ulceration [ 10– 10].
Figure 4 illustrates a novel carcinogenesis model for intramucosal differentiated-type adenocarcinomas that relies on their mucin phenotypes.
In 2004, the terminology for squamous VIN was reviewed by the ISSVD that classified VIN in two groups: usual type (uVIN) and differentiated type (dVIN).
† Well or moderately differentiated adenocarcinoma and papillary adenocarcinoma were categorized as differentiated type.
