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There is precedence for differential sensitivity between cells and organisms.
Such a mechanism may be also responsible for differential sensitivity to 16- and 14-membered macrolides in staphylococci.
To investigate whether p53 status in cancer cell lines is responsible for differential sensitivity to BRD4770 treatment, we tested BRD4770 in five human cancer cell lines.
Enrichment of changed genes involved in lipid metabolic processes is consistent with our previous proposal of inherent differences in energy regulation between AHR-variant animals and may pose as a potential explanation for differential sensitivity to TCDD-induced body wasting.
To test for differential sensitivity to γ-rays and UV light, cells were plated in culture medium, irradiated with Cs γ-rays or UV, and then incubated at 39.5°C for 48 hr.
At this juncture, it seems unlikely that differences in the ability of vorinostat to inhibit HDAC activity or regulate the expression of key genes are the primary hypothetical mechanisms for differential sensitivity of tumour and normal cells to this agent.
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The aforementioned findings also suggest that neurodevelopmental maturing cognitive systems are likely to be important substrates for differential sensitivities to the environment.
Using a clone of the DLD1 colorectal cancer cell line differing only in the mutational status of RAS, a so-called isogenic clone, they screened almost 75 000 shRNA vectors (covering most of the genes in the human genome) for differential sensitivities (Fig. 4).
10.7554/eLife.06604.005 Figure 3. Procedure for determination of differential sensitivity to multipoint correlations for a stimulus pair.
Methodology of differential sensitivity analysis and sensitivity-based aggregate simulation for formation pressure, temperature and fluid flow is developed here.
As a constant parameter, the organic solvent DMSO cannot be responsible for the differential sensitivity levels of AaOR8 and notably for its remarkable enantioselective capabilities.
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