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Patients who experienced several toxicities calling for different recommendations were placed on the lowest recommended dose.
Despite evidence showing benefits of these recommendations, the proportion of endorsing journals has been moderate to low and varied considerably for different recommendations.
The balance between individual and speciality biases in guidelines development groups could, in part, account for different recommendations on who provides follow-up and in what setting.
The reasons for different recommendations might be expected to include: NICE sometimes allowed cost per QALY exceeding the upper bound of its cost-effectiveness threshold (£30 000 per QALY); especially after the 'end-of-life' additional guidance was adopted.
Similar(56)
HTA agencies reached the same recommendation for reimbursement (recommended for listing) for four drugs and different recommendations for five drugs.
Marsh et al. [ 69] pointed out that the scientific basis for the different recommendations is generally weak.
For example, there are twenty-two differecommendationstions for vitamin D cited for adults aged 70 years or older in Europe.
The quantitative analysis showed that the panel disagreed about the criteria suggesting that reporting of sub-group analysis is only justified in cases where the magnitude of the difference is large enough to support different recommendations for different sub-groups.
In this set of strategies, the recommendation for the immunocompromised group is fixed, and different recommendations for the healthy and immunocompetent/comorbidities groups are explored.
From a methodological perspective, these temporal differences suggest different potential uses, or different recommendations for what measure to use within a particular study.
The panel disagreed about the recommendation that sub-group analysis is only justifiable in cases where the magnitude of the difference is large enough to support different recommendations for different sub-groups.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com