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In order to explore the variation in output across the varying parameters, box plots were plotted for different parameter configurations.
Because it is hard to define general rules to analyze the effects of noise in population-averaged input-output measurements, we performed a sensitivity analysis on the two-module network with the TetR/Ptet-based NOT gate to explore the system response for different parameter configurations and to estimate the parameters of highest impact.
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We observed that, even when we allowed for greatly different parameter configurations, the connecitvities modelled by the magenta and grey models are still chemotactic, hence our invalidation is robust.
The simulation of this population average was then repeated for each of the 1000 different parameter configurations represented in the posterior sample (the entire posterior simulation therefore involved a total of 10 simulated patients), resulting in inferences that reflect posterior parameter uncertainty as well as intertrial and interpatient variation.
In Table 1, we also add four different parameter configurations that will be used for global throughput evaluation.
c A more complex DAG connects different parameter configurations.
under different parameter configurations, where the performance is measured in terms of HL, maF1, and miF1.
Many more results, under different parameter configurations, are given in the Additional file 1.
We experimentally tested different parameters configuration for the model.
Model fits were compared for different predictive algorithms and parameter configurations by plotting receiver operating characteristic (ROC) diagrams and assessing the area under the curve (ROC-AUC) in a separate subset of patients (holdout method with a test sample that consisted of 33% of all patients).
First configuration step (shape constraints neglected): average MSPD ϕ obtained by comparing automatic results on brushstroke width with observations by human subjects for different configurations of parameters r m and r M. The configuration providing the best trade-off for all the observations was the one represented by r m =0.01 and r M =0.04, as shown in Figures 6, 7 and 8.
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