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There is a significant need for developing compounds that kill Cryptococcus neoformans, the fungal pathogen that causes meningoencephalitis in immunocompromised individuals.
One set of building blocks, (5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-6-ylmethyl)amines, proved useful as a scaffold for developing compounds that stimulate glucagon-like peptide-1 (GLP-1) secretion and are novel anti-diabetes drug leads.
As shown in our phylogenetic trees, parasite kinases are divergent from human host homologs suggesting potential scope for developing compounds with specificity to bind Leishmania, Trypanosoma or Plasmodium PIKs.
Ultimately, refining our understanding of how parasites move through 3D space will improve strategies for developing compounds that can hinder them, either as transmission blocking drugs or as effective treatment drugs that target other stages of the life cycle.
Therefore, to overcome MDR, it is important to understand how this transporter exerts its function and how its expression is regulated, as this information may provide clues for developing compounds that modulate BCRP activity.
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Co-planar grid detectors utilizing single carrier sensing techniques, offer a practical solution for developing compound semiconductor gamma-ray detectors with high resolving power.
As the first step to underline the utility of the GT RL method in solving complex multi-agent multi-reservoir problems without a need for developing compound objectives and weight assignment, the proposed method is applied to a hypothetical three-agent three-reservoir system.
In Nigeria, NIPRD was the first in a series of partners developing compounds for sickle cell anemia (see the Niprisan paper in this BMC series).
Pharmacopeia, which makes software for drug makers and develops compounds for potential medicines, said yesterday that it planned to spin off its drug-discovery business, change its name and move to San Diego.
And you can use them to develop compounds for clinical settings.
"I work with metals (both radioactive and nonradioactive) to develop compounds for diagnosing or treating various diseases and other compounds used in detecting or removing radioactive compounds from the environment," says Jurisson.
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