In the absence of definite proof of dorsal root ganglia involvement or other gold standard, we provisionally classified the SNN patients in the study population according to two levels of certitude for the diagnosis of SNN.
The JUVENTAS (reJUVenating ENdothelial progenitor cells via Transcutaneous intra-Arterial Supplementation) trial is the first randomized, placebo-controlled, double-blinded clinical trial on repeated intra-arterial BM mononuclear cell (MNC) infusion in 110 to 160 CLI patients, designed to provide definite proof for the efficacy of stem cell therapy.
Thus, also a limitation of the present study is that we did not determine the effect of sEH inhibition in animals lacking LOX activity and therefore we cannot provide definite proof for an involvement of LOX in the progression of renal failure after sEH inhibitor treatment.
This study provides definite proof for the absence of the putative 'red' chlorophyll trimer in Synechocystis and narrowed the number of coupled pigment dimers to two.
Definite proof for a reduced chemosensitivity of advanced dMMR tumours can only be obtained from prospective randomised studies with chemotherapy vs observation.
Although the high affinity is consistent with the formation of a Cys2His2 complex, definite proof for such coordination should come from X-ray structure determination and/or EXAFS.
Definite proof for prospective prediction mechanisms can only be found in studies that are able to uncover the purely endogenous neural activity associated with the generation of predictions.
Although definite proof for the time and place of domestication is lacking, Mexico is presumed to be the most probable region of domestication, with Peru as the centre of diversity for wild relatives (Larry and Joanne, 2007).
The reduction in T-cell numbers in blood does not provide definite proof for an extravasation of the cells, as they might have only attached to the endothelium, thus remaining undetected in the circulating blood.
Molecular mimicry at the level of CD4+ T cells is suggested to be involved in several autoimmune diseases, including JIA [ 14, 18- 24], although definite proof for such a mechanism is lacking in most cases [ 17].
