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Optimal cut-points for continuous variables were determined using Receiver Operating Characteristic (ROC) plots for BCR and BCS at 5 years after surgery.
p Values for continuous variables were determined using analysis of variance or the Mann-Whitney U test, and for categorical variables using the χ test.
*P-values for continuous variables were determined using 2-sided (Wilcoxon) rank sum tests P-values for categorical variables were determined using Chi-square tests The majority of participants received supplemental isotonic fluids in addition to the study fluid.
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Equality of variance for continuous variables was determined using the Brown-Forsythe and Levene test.
Differences between continuous variables were determined using t test.
Correlation between continuous variables was determined using Spearman's rank correlation coefficient.
P-values for continuous variables and categorical variables were determined using the Mann–Whitney test and the χ-test with Yates's correction, respectively.
To predict treatment outcome, cut-off points for continuous variables were determined by receiver operating characteristic (ROC) curve analysis.
Comparability between the case and control groups for categorical variables was determined using the χ test for categorical variables and the two-sample t test for continuous variables.
Differences between the two groups were determined using Student t-test for continuous variables.
Intergroup differences were determined using Student's t-test for continuous variables and the Pearson chi-square test or Fisher's exact test for categorical variables.
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