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Patients aged 18 years and older with at least one prescription claim for exenatide or glargine from October 1, 2006 through March 31 , 2008were selected and screened for continuous eligibility for the 12 months pre- and 18 months post-index period.
Additional criteria for continuous eligibility was not applied; however, patients who were Medicare and/or health maintenance organization (HMO) eligible anytime during the two-year period were excluded in the Medicaid database, in order to ensure the availability of all claims within this database.
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Potential controls were then screened for 6 months of continuous eligibility with medical and pharmaceutical benefits prior and 12 months subsequent to their respective index dates.
Covariates were added to the model to adjust for the presence of known risk factors for MI and CVA during the 183 days of continuous eligibility preceding the index date.
It was also required that patients have at least 1 prescription claim for saxagliptin or sitagliptin between January 1 , 2010 and December 31, 2011, at least 6 months of continuous eligibility before treatment initiation (baseline period), and at least 6 months of continuous eligibility after treatment initiation (follow-up period).
For each claim, members were required to have had continuous eligibility for at least 60 days before and 15 days after the claim date of service.
Only patients with continuous eligibility for at least 24 months (12 months before and 12 months after the enrolment date) were included.
Only patients with continuous eligibility for at least 24 months (12 months before and 12 months after the enrollment date) were included.
Patients had continuous eligibility for 1 year before through 1 month after the index date for baseline testing outcomes or through 1 year after the index date for annual testing outcomes.
‡Adjusted for age, gender, study wave, targeted preference-sensitive condition (overall model only), prior year's facility, physician, ancillary, pharmacy costs, Health Coach communication in the prior year, continuous eligibility for the study period.
The exclusion criteria having the greatest impact on the sample size were the requirements of not having an osteoporosis treatment in the pre-period and having continuous eligibility for 18 months.
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CEO of Professional Science Editing for Scientists @ prosciediting.com