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Kaplan Meier estimates of DFS at 5 years were 0.51 for CMF, 0.56 for CMF → GT, 0.53 for A → CMF and 0.71 for A → CMF → GT.
The estimated OS at 5 years were 83% for A → CMF vs 79% for CMF.
At multivariate analysis, HR was 0.86 for CMF → GT, 0.86 for A → CMF and 0.53 for A → CMF → GT as compared to the reference CMF arm.
Conditions of service were the same as for CMF units in Australia, while PNGVR members were paid the same as their Australian Regular Army ARAA) counterparts.
Canonical pathways for cMF vs. cLF differentially expressed gene set.
Overall median survival was 16 months for MMM and 12 months for CMF.
Similar(32)
For CMF-based treatment regimens, the incidence of neutropenic events (predominantly dose delays) was highest with CMF 3-weekly regimen.
Table 5 Sources for models able to quantitatively estimate safety benefits of the different measures considered Pilot projects PP1 PP2 Set of countermeasures Set A Set B Set C Set D – Possible methods HSM base [6]/calibrated [48] x x x x Cafiso et al. (2010) [28] (Eq. 6) x x Russo et al. (2016) [30] (Eq. 7) x Other sources needed (e.g. for CMFs: [35, 50]) x x .
Like CD3, TIA-1 had no significant prognostic relevance for CMF-treated patients (log-rank HR = 0.60; 95% CI, 0.21 to 1.71; P = 0.3397).
For CMF-based regimens, the risk increased almost two-fold to a 1 : 2 risk, whereas for anthracycline-based regimens, the risk increased almost 2.6-fold to a 3 : 4 risk.
Thus, we found cultured tumour-derived fibroblasts/myofibroblasts (GMF for gastric and CMF for colon) to produce significant amounts of G-CSF.
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