We considered that the image-dense data required to implement our method may pose a potential obstacle for clinical implementation.
The need for a largely common list of biomarkers across four datasets resulted in a final list that was composed nearly exclusively of markers that are (i) common; (ii) used often in clinic; and (iii) cheap, increasing the relevance of any results for clinical implementation.
Recommendations for clinical implementation of screening for distress call for routine screening in the clinic, at critical care points.
For clinical implementation and routine use, the ideal biomarker is highly specific for a particular disease condition and is measurable in easily accessible body fluids, such as saliva, serum, or urine.
These studies will help demonstrate the value of PGx for clinical implementation and may inform clinical guideline recommendations.
However, the existing biophotonic techniques fail to achieve the satisfactory treatment efficacy, which remains a big challenge for clinical implementation.
Root ZX can be strongly recommended for clinical implementation of endodontics in primary teeth, particularly when treating fidgety children.
Our proposed methodology is well-suited to automated detection and measurement, which are a prerequisite for clinical implementation.
As discussed here, diverse strategies of chimeric Ad development have overcome preexisting immunity, inactivation by blood factors, unfavorable biodistribution, or insufficient infectivity and oncolysis, paving the way for clinical implementation of Ad-based therapies.
We conclude that immune functions are corrected in Rag2−/− mice by genetic modification of stem cells using the UCOE driven codon-optimized RAG2, providing a valid optional vector for clinical implementation.
In light of the large numbers of variables intrinsic to biomarker studies, validation of preliminary data for clinical implementation presents a significant challenge and may only be realized with large trials that involve significant patient numbers.
