By 1995, STI571 was a lead compound set for clinical development.
Alan Metz, vice president for clinical development at Glaxo, said the company was not warning American doctors against using the drug for depressed children.
"In psoriasis, you get a pretty easy readout -- you look at the skin," said Gisela Schwab, vice president for clinical development for Abgenix, which has chosen psoriasis as the first disease to try to attack with its antibody technology.
"You get a lot of 'parking lot' diaries, which people fill in in the parking lot before handing them in," said Susan Rodriguez, vice president for clinical development at Pherin Pharmaceuticals of Mountain View, Calif., the maker of PH80.
Ann Baker of Accenture, a consultancy, says that most firms are nowhere near their goal of tripling the output of molecules for clinical development.
The bridegroom's father is senior vice president for clinical development and regulatory affairs at ZARS Pharma, a pharmaceuticals unit of Nuvo Research of Canada.
One representative thereof, carmegliptin (8p), was chosen for clinical development.
The company's first targeted human tissue printed for clinical development were cells called "islets of Langerhans," which are the units within a pancreas that produce insulin.
Concurrently, monoclonal antibodies and peptide-based agents provide independent options for clinical development.
Among the various compounds under investigation, KFA-1982 was selected for clinical development.
One representative thereof, Aleglitazar ((S -2Aa), waS -2Aaen for clinical development.
