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But patients could not already have been prescribed opioids for chronic use.
It's not possible yet to make that power source small enough that it could be conveniently either implanted or worn by the patient for chronic use.
For example, the statement in the ICHS6, "for those biopharmaceuticals intended for chronic use indications, studies of 6 months duration have generally been appropriate…"; is this still relevant?
Since the act passed, the median launch price of orphan drugs for chronic use has doubled every five years, according to an analysis presented in May by a team of Massachusetts researchers.
Lunesta is the only sleep drug with an indication for chronic use, and has better sleep data than other drugs in the category.
Previously, therapeutic potential for FGF19 in the treatment of obesity and diabetes has been proposed [3], [4]; however, its promotion of hepatocyte proliferation and carcinogenic potential challenges the development of FGF19 for chronic use [15].
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The U-PRIM software screens the medication list for chronic drug use, using anatomical therapeutic chemical (ATC) codes.
These issues regarding physiological reserves are also important for the chronic use of inhaled insulin, which causes an early reduction in lung function (26).
Frequent use served as a convenient proxy for long term chronic use.
It also introduces alternative buffers that may be more applicable in a clinical setting for acute or chronic use.
Assessment of bleeding risk is often crucial for making decisions regarding chronic use of antithrombotics.
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