Suggestions(1)
Exact(13)
However, further investigation is needed on several other types of genotoxic assessments, especially for chronic effects.
The high-end risk expressed as the combined probability of short-term exposure and acute effects to a sensitive species indicated no concern in 99% of cases with limited opportunity for chronic effects due to the rapid decline of Cry1A(b) from the environment.
Smaller effect estimates were also observed for chronic effects without mutual adjustment.
The choice of 2050 ensures that the time period under consideration is long enough to account for chronic effects.
These preliminary findings appear to indicate a correlation between readily determined physical properties and the potential for chronic effects in this class of compounds.
Brook (2008) proposed generation of a chronic proinflammatory state as a major mechanism for chronic effects of ambient particles upon the cardiovascular system.
Similar(47)
As we have found similar oscillation suppression after chronic exposure to either WIN or THC two structurally different cannabinoids that both act as CB1R agonists we suggest that CB1Rs may be responsible for the chronic effects that we observe.
The current study was conducted to determine the importance of the ventral hippocampus for the chronic effects of nicotine.
Finally, the 2-year period may not have been long enough for the chronic effects of high dose NSAID use on eGFR decline to become apparent.
In addition, the anxiolytic- but not antidepressant-like profile may reflect the difference in the kinetics of treatment for both conditions, with acute effects for anxiolytic compounds versus chronic effects for antidepressant molecules.
We address three issues in our discussion: (i) validity of the assay protocols that we have used; (ii) interpretation of the specific results for the substances that we have tested here; and (iii) general questions concerning the use of model systems for testing the chronic effects of substances that are used medically or recreationally for long periods by human subjects.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com