Dayveon was part of the NEXT lineup, which has traditionally been the ripest ground for the kind of challenging discoveries that makes Sundance so fun.
These interfaces, however, are more challenging for inhibitor discovery.
However, as gene expression has temporal and spatial changes, the sample preparation is more challenging for SNP discovery because it requires the same set of ESTs generated from different genotypes that can be compared with each other.
Both present interesting and challenging drug discovery opportunities.
Nowadays, identifying weak motifs and reducing the effect of local optimum are still important but challenging tasks for motif discovery.
The cytoplasmic scaffolding protein NF-κB essential modulator (NEMO), also known as IκB kinase γ (IKKγ), is a compelling but also a challenging target for drug discovery.
However, analysis of such fluids for initial biomarker discovery is challenging because of high salt content, very wide dynamic range of protein concentrations and dominance by a small number of proteins present in high concentrations (Hanash et al, 2008).
Urine post-DRE is achievable for all men suspected for prostate cancer; thus it represents a minimally invasive and challenging starting material for biomarker discovery.
Voided urine obtained immediately after DRE is greatly enriched in prostatic cells (about 80%) and thus represents a challenging starting material for biomarker discovery in oncological research.
Some MS techniques, such as those for targeted analysis, are being successfully applied for biomarker verification, whereas others, including global quantitative analysis (for example, for biomarker discovery), are more challenging and require further development.
