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For cases showing negative staining for IDH1 R132H, DNA sequencing for IDH1 and IDH2 was analyzed.
Thus, significant differences on survival times were found for cases showing a high LVD (poorer outcome).
For cases showing mixed intensity, the predominant intensity was selected as the final IHC score.
For cases showing any degree of aneuploidy, there was a trend towards a higher proportion of aneuploid cells among good prognosis tumours but, again, this did not achieve significance.
FISH with the PathVysion probe and immunohistochemical assay with Herceptest are highly concordant for cases showing 3+ IHC scores and for negative cases, although the 2+ IHC score group includes both ERBB2 amplified and non-amplified tumors, showing a relatively high rate of discordance [ 25, 26].
Similarly, while SAM [ 8] and LIMMA [ 9] do not require a rigorous normal distribution and -especially the latter- shows good performance when the sample size is small, we observed that they are not robust enough for cases showing dramatic deviation from normality, a fact also mentioned in LIMMA's manual.
Similar(53)
Similar for case shown in Figure 9 (2PC0), detailed comparison with NMR data (if they are readily available) and comparison to single conformer ADP refinement.
Transient responses for other cases show similar trends.
A conventional friction coefficient of 0.4 is assumed for the cases shown here.
Bottom left: the two stimuli curves (black and red) with perturbation size 3 (sinusoidal curve shown in blue) used for the cases shown in green in top panels.
This conclusion is further supported by corresponding T-index scores higher than 0.8 for most cases shown in Tables S1 and S2.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com