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Although it is likely that these genes truly are involved in the pathogenesis of RA, this remains to be proven; as for candidate studies, this type of reasoning is counter to one of the main aims: hypothesis-free generation of new knowledge.
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For selecting candidate studies for this review, we searched online bibliographic databases for peer-reviewed articles and working papers.
The systematic review identified 567 candidate studies for screening.
Findings from these studies can then be used for candidate gene studies to further elaborate on possible drug gene interactions.
Adequately powered studies are necessary; however, there are currently limited data available to allow precise estimates of effect sizes for candidate gene studies.
Array-based genotyping technologies that have enabled GWAS also permit flexibility in choosing the scope and density of SNPs for candidate gene studies.
Even for candidate gene studies, this effect can critically hamper the association analyses since natural selection can greatly affect genetic diversity at disease genes [30].
Affiliated laboratory facilities include a medium/high-throughput platform for candidate gene studies and GWAs analyses.
For candidate gene studies, pre-requisite knowledge is necessary, for example, the location of the candidate genes.
Affiliated laboratory facilities include a medium/high-throughput platform for candidate gene studies and genome wide association (GWA) analyses.
Controlling for multiple testing is important even for candidate gene study.
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