Sentence examples for for bulky groups from inspiring English sources

There is also a close correlation between descriptors and molecular weight, especially for bulky groups.

For bulky groups, such as CF3, multiple "1,4 -additions are to be expected.

In addition, intrinsic flexibility in the S4 pocket allows for the accommodation of bulky groups such as benzene rings, suggesting that this structural plasticity can be further exploited for optimizing inhibitor enzyme interactions that should promote a tighter binding mode.

The model provided with hydrophobic descriptors in positive side indicating the need of bulky groups, steric and electronegative descriptors in negative coordinates hints with contribution by the electronegative substitutions as favourable and desirable moieties for enhancing the activity.

However, electron-withdrawing group and bulky groups appeared unfavorable for the reaction.

Structural comparison between these new indazoles further supports the importance of the aromatic indazole skeleton for NOS inhibition and indicate that bulky groups or N-methylation of 1 and 2 diminish their effect on NOS activity.

The decrease in particle size in modified ZnO could be due to possible coating during synthesis process where exposed bulky groups provide steric hindrances for nucleus agglomeration.

When this gatekeeper residue is mutated to a small residue (glycine or alanine), a unique pocket is formed that will allow for the binding of promiscuous inhibitors with bulky groups allowing specific inhibition of this mutant allele.

In 2013, the same authors obtained some improvement for these aryl aldehyde substrates by incorporating sterically bulky groups into the catalyst (Scheme 96).

Remarkably, the moderate isolated yield was obtained for the challenging coupling of the amine bearing very bulky groups.

The results of 3D-QSAR analyses indicated that hydrophobic and negatively charged groups at 6th position of benzothiazole ring and positively charged and bulky groups at ortho position of phenyl ring are favorable for high activity.