Five of 12 previously identified expression quantitative trait loci (eQTL) hotspots coincide with CNVs, demonstrating the potential for broad influence of CNV on the transcriptional program and phenotypic variation.
During the war of 1244 46 David contended for a broader influence, but his promising endeavour was cut short by his early death in 1246, without heir.
Surely now recognition as the greatest ever women's tennis player is no longer a point of dispute but a jumping-off point for her broader influence across society at large.
Support for a broader influence of the ACE I/D polymorphism on metabolic regulation is provided by elevated muscle transcript levels of transcriptional regulators of lipid (i.e. PPARA) and carbohydrate/mitochondrial metabolism (i.e. HIF-1a, VHL) and three glycolytic factors after single or repeated exercise in carriers of the ACE I-allele (Fig. 4).
We did not account for the likely broader influence 19 of our cohort of global celebrities on the much larger population of fans and followers worldwide (average of 6.5 million Facebook likes per cohort participant), thus underestimating the overall R0, analogous to the "super spreader" concept.
Based on these results, we believe the networks are useful in modeling the impact of the OVOLs and the four other TFs in MET, and may be appropriate for understanding broader influences in MET across multiple cancer types.
Indeed, some of the most notable philanthropy on the part of Giving Pledge signatories has shared Peter Thiel's knack for combining tangible effort with broader influence through discussion buzz, if you will.
Only a small number of individuals have a broader influence.
Here, my work will have broader influence.
Its worth pointing out that, despite my top 5 list here focusing on electricity generation, there are other challenges: reducing our demand for electricity, and broader influences such as population and economic activity, for starters.
