The generality of their methodology should enable Smit and his colleagues to develop force field models for broad combinations of different metals, linkers and topologies.
Beyond improved glucose control, novel treatments would ideally provide a reduction of cardiovascular risk, with a favorable impact on excess weight, and a low intrinsic hypoglycemia risk, as well as a synergistic mechanism of action for broad combination therapy.
A search for additional domains in proteins containing thyropin regions gives a broad combination of different domains (see Additional file 3).
7 A broad combination of factors can trigger and sometimes amplify avian influenza outbreaks (98, 99).
To compare the experimental and simulation density profiles for a broader combination of parameters we used an estimate of the least–squares error, Error DP (D, q), to determine whether there is an optimal choice of D and q to match the cell density data [see methods Assessing goodness of fitand Equation 4].
All spectra shown in Fig. 3 were mathematically corrected for the broad combination band of liquid H2O at around 2120 cm−1 and normalized to unity.
Although limited to results obtained with the two cell lines used for the broad combination screen (LCC6 and LCC6Her2) it is interesting to note that the 267/Dt combination was synergistic while combinations of 267 with paclitaxel and vinorelbine appeared antagonistic.
Critics have praised the movie for its combination of broad humor and a humanist message, and its ability to poke mild fun at a physical disability.
Another criticism refers to the fact that the beneficial effects were specific and momentary, i.e., they were neither maintained in the long term nor generalized to other contexts, suggesting the need for broader programs or for the combination of general and specific interventions in the skills to be improved (Melby-Lervåg & Hulme, 2013; Rapport et al., 2013).
The so-called broad diagnosis for CSX, a combination of 2 inclusion criteria (angina pectoris and normal coronary arteries) was used only in four studies (7%).
