Your English writing platform
Discover LudwigSuggestions(1)
Exact(1)
For our highest-synergy pair (RBP1 with EEF1B2) we found P < 10-15 for both permutations A and B. To examine the effectiveness of estimating the Gumbel distribution using 100 permutations, we ran the following simulation experiment.
Similar(59)
For both permutation types, 1000 permuted samples are created, and the perturbation scores for each permuted sample is calculated.
We also make recommendations for the appropriate number of permutation samples to use, in order to achieve a desired level of accuracy for both permutation procedures using distributional theory.
We explored the distribution of individual tests of the permuted hypergeometric results (i.e., distribution of P values for each pathway-trait combination for both random permutations and the circular permutations).
Moreover, it is demonstrated that the D-efficiency remains unchanged for both level permutation and column permutation in some special cases.
These differences were significant for both parameters (permutation tests, Rs: P = 0.001; He: P = 0.027).
Genetic differentiation tests reveal a similar contrast between agricultural and hunter-gatherer populations; as expected African and non-African populations are significantly differentiated for both DEFB127 (Hst permutation test, p = 0.008) and DEFB132 (p < 0.0001), but for DEFB132 the agricultural and non-agricultural populations are also differentiated (p < 0.0001).
The most significant P-value from the likelihood ratio tests is used in the permutation test with 1000 permutations for both the two-way and three-way models.
For both popCons and popUncons permutations, we also ensured that no permuted elements had fewer than 80% of base pairs passing the 1000 Genomes Project's coverage and quality cutoffs in the same manner as described above for our filtering of popCons and popUncons elements.
P-values were based on 1000 permutations for both PGMDR and FAM-MDR, hence no stopping rules were used.
The time required was approximately 8 seconds for both data sets excluding permutations.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com