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Hemingway's own suicide, by shotgun, in 1961, at his hunting retreat in Ketchum, Idaho, brought a palette of tragedy to the story, even though the much discussed curse of the Hemingways seems no more than a gene for bipolarity that bounced around fiendishly from generation to generation.
For bipolarity read equivalency.
It is furthermore interesting to note that the native concentration of Eg5 in extract is above this critical concentration required for bipolarity.
The existence of a critical concentration for bipolarity might be a conserved feature of spindles in higher eukaryotes, as the efficiency of bipolar spindle formation was also found to be dependent on the amount of kinesin-5 on the spindle in Drosophila S2 cells [20].
When the IFES was explored in a non-clinical sample in relation to risk for bipolarity, IFES Total Score was positively associated with risk for bipolarity (Deeprose, Malik, & Holmes, 2011).
The presence of psychotic features in the course of a depressive disorder is known to increase the risk for bipolarity, but the early identification of such cases remains challenging in clinical practice.
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DSM-5 has fortunately replaced DSM-IV's vague group NOS by defining MDE with several subthreshold conditions of bipolarity, for instance, allowing a duration of 2 to 3 days for hypomanic episodes, as suggested by child psychiatrists, or fewer than four symptoms of hypomania during 4 days, or, for cyclothymia, specifying shorter manifestations (<24 months).
For quantification of bipolarity, hyphae were observed with a 63× Plan-Apochromat objective in combination with a Spot Pursuit CCD camera.
This result illustrates that the phosphorylation of Eg5 by Cdk1 controls also the apparent affinity of Eg5 for spindle microtubules in Xenopus egg extract, thereby ensuring that the amount of Eg5 in the spindle when present at the endogenous concentration in the extract is well above the critical value required for spindle bipolarity.
KIF2A was found to specifically localize in centrosomes during the process of cellular mitosis, and possesses microtubule-depolymerizing activity for spindle bipolarity [ 14, 16].
Another potential source of resistance is the expression of KIF15, a KIF that becomes essential for spindle bipolarity when Eg5 activity is partially blocked (Tanenbaum et al, 2009).
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