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The identification and validation of these 'proximal' biomarkers (ie, mechanistic biomarkers; Figures 1 and 6) will be pivotal for better defined decision-making points to enhance drug development as well as improve medical management of SUDs such as cocaine dependence.
These issues highlight the need for better defined surgical appropriateness and improved shared decision-making tools [ 12].
There is still a need however for better defined approaches to enable research funders to determine the relative weight to assign to disease specific research versus HPSR and other forms of cross-cutting health research.
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Likely, the increased attention paid in recent years to the dirofilariosis issue from the "one health" perspective is creating the basis for better define the impact of dirofilarioses on humans and to plan suitable measures to prevent these often neglected infections.
Based on the dimensionless groups derived we proposed a new dimensionless group for better defining the effectiveness of the process.
A reliable and low-cost typing system is required for better defining the epidemiology of this pathogen and designing more rational policies of infection control.
Our model is particularly important given that this topic is so difficult to study prospectively, due to the small number of HIV-infected infants born in the U.S. Multi-centre clinical trials are an important tool for better defining maximally effective and cost-effective interventions for prevention of vertical HIV transmission, especially with mothers at risk of medication non-adherence.
These studies were useful for better defining content of risk mitigation advice messages and the audience they should primarily target.
Reduction of the QTL interval with large populations and dense marker maps for fine mapping is valuable in this context for better defining candidate genes underlying mapped loci.
There is still work to be done for better defining the mechanisms of miRNA-associated paclitaxel resistance and its potential as a future target for therapy in OC.
Sepsis, regardless of severity level, is undercoded, but with the improved Sn and high NPV, these definitions can be used for better defining cohorts of patients with sepsis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com