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We used BioEdit software [ 5] for basic manipulations with nucleic and amino acids sequences.
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We propose a mathematical labeled tree (a hierarchical graph structure) to abstract the manipulations performed for an experiment: vertices represent basic manipulations or morphologies and edges connect the manipulation outputs and inputs.
The libSBGN (van Iersel et al., 2012) enables basic manipulations of SBGN-ML files, a text-based exchange format for SBGN graphics, but it does not provide methods for interactive visualizations.
The basic manipulations consist of sub-setting the data, selecting grouping variables for the samples in the datasets, identifying differentially expressed genes, cluster analysis, assessing enrichment of differentially expressed genes within the query list, etc.
All basic manipulations produce one output, i.e. a piece.
DNA sequence viewing, editing and basic manipulations were performed using Bioedit [ 51].
These basic manipulations can be applied in any combination during the preparation of an experiment.
It also performs basic manipulations and analyses of the structures of protein ligand complexes.
For most applications, the structure of the data elements and their basic manipulation lie at the core of the design.
This was basic manipulation at its finest e.g. "I was a jerk?
However, relatively low efficiency and lack of remoblization of these transposons in the mosquito germline hinders genetic manipulations for basic research and for exploring new disease control strategies [24].
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