Sentence examples for for axonal function from inspiring English sources
NAA is an amino acid produced by mitochondria in neurons, and the NAA/Cr ratio is regarded as a measure for axonal function and integrity.
BMP signalling is important for axonal function.
Both oligodendrocytes and Schwann cells are essential for axonal function and integrity.
This suggests that endosomal abnormality, perhaps resulting in dysregulation of one or more receptor-mediated signalling pathways important for axonal function, could be an important cause of HSP.
Microtubules are also critical for axonal function and provide the major transport route for essential organelles to distal nerve endings [ 2].
This study found that mutant HTT is differentially distributed in neurons, implying that HTT aggregates may associate with cytoskeletal machinery to undergo directed transport, a process highly relevant for axonal function.
The CMOS-based MEA presented here provides a system to record and stimulate individual neocortical axons at hundreds of sites, which offers a technological advancement for the study of axonal function.
All together, these findings indicate a progressive impairment of axonal function, which may include axonal instability, defective axonal transport, deregulated ion channels function and/or abnormal interaction with myelin sheaths.
For many decades, the only method available for accessing axonal function involved evoking antidromic (propagation towards the soma) action potentials in axons by extracellular stimulation at a specific site of the axon and then recording elicited somatic responses18,19.
In white matter, oligodendrocytes rather than astrocytes supply axons with lactate via MCT1, which is essential for proper axonal function [ 16, 22].
Since BMP signalling is important for distal axonal function, we propose that dysregulation of BMP signalling could be a unifying pathological component in this endosomal group of HSPs, and perhaps of importance in other conditions in which distal axonal degeneration is found.
