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By 1996, experts like Prof. Jeremy B. Rutter, head of classics at Dartmouth, judged the chronological gap too extreme for any linkage.
To adjust for underestimation of rates using the linked datasets, and to correct for any linkage bias whereby the percentage of eligible cancer records linked varied by socio-demographic characteristics, we calculated weights for strata of age, sex, ethnicity, region, small area deprivation, and time since census.
As for other epidemiological studies solid evidence for any linkage is not obvious but it is irrefutable that platelet studies have been invaluable in enabling an insight to be gained into the role of serotonin in a number of psychiatric and neurological disease [ 39, 41].
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When trying to decide whether solid Earth tectonic forces or climate and surface processes control the structural evolution and exposure history of mountains, it is important to have an independent climate record to compare with erosional reconstruction in order to test for any linkages.
The quality of any linkage relies on the amount of information available for linkage as well as that information's accuracy, consistency and completeness.
In Fig. 3(a) corresponding to each region of origin we show a comparison between the number of families that could be linked to those for which any linkage was not detected.
The CHeReL undertakes quality assurance for any data linkage and assesses the linkage quality by manually reviewing personal identifiers for a sample of the records obtained for linkage.
For any record linkage project, two questions must be answered: 1) What is the best way to achieve a high linkage rate in a cost-effective manner?
If the linkage method outlined in this article is found to be practical for a particular study, then as for any such linkage studies using data initially gathered for other purposes and so without participant consent for the proposed linkage agreement and clearance would need to be obtained from a properly constituted ethics committee or ethics review board.
For each Atlantic salmon linkage group, a single synteny relationship was assigned only if the number of significant alignments for a particular stickleback linkage group was twice (or more) than the number of significant alignments for any other stickleback linkage group, and this relationship was seen in all mapping parents.
However, such an approach wastes a great deal of effort in genotyping large areas of the genome that are eventually found not to show any evidence for linkage.
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