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This kind of phenotype screen may reveal molecules that affect the same cellular functions as Ecs and result in identification of new lead molecules for antimicrobial development.
Previous reports have established that a targeted peptide can disrupt the TA interaction (Lioy et al. 2010; Chopra et al. 2011) and the utility of TA disruption for antimicrobial development (Lioy et al. 2010).
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This finding suggests that inhibitor development against core macromolecular processes may be a fruitful avenue of antimicrobial development for both replicating and nonreplicating M. tuberculosis.
Certainly, it would need a deep remodel of the current drug regulation for new antibacterials and to adequately stimulate investment by the industry for new antimicrobial developments and ultimately to non-antibiotic approaches.
This also highlights the significant unmet medical and antimicrobial development need for rapid diagnostic platforms that can reduce the time to identification of the etiology and extent of bacterial bloodstream infection.
These results indicate that Pep-1-K may be a good candidate for antimicrobial drug development, especially as a topical agent against antibiotic-resistant microorganisms.
Analysis of the crystal structure in the context of other homologous enzymes from pathogenic fungi and human sources sheds light into the suitability of SDH as a target for antimicrobial drug development.
This work provides actual new insights that may help the investigation for new targets for antimicrobial drug development.
The mutant phenotype clarifies the functional role of Ecs in S. aureus and other gram-positive bacteria as well as the potentiality as a novel target for antimicrobial drug development.
These virulence factors serve as targets for antimicrobial drug development (Tomioka et al. 2011; Wang et al. 2013; North et al. 2013).
DHQS acts on the substrate 3-deoxy d-arabinoheptulosonate 7-phosphate [DAHP] as part of aromatic amino acid biosynthesis and has been well-studied because it is a target for antimicrobial drug development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com