Sentence examples for for antibody humanization from inspiring English sources

In this paper, we describe procedures for antibody humanization with an emphasis on strategies for designing humanized antibodies with the aid of computer-guided modeling of antibody variable domains, using as an example the humanized anti-CD25 monoclonal antibody, Zenapax.

So far, many approaches have been used for antibody humanization, such as chimeric antibodies, which consists of murine antigen-binding variable regions fused genetically to human antibody constant regions, is the earliest attempt to reduce immunogenicity [7].

Here we present tools for antibody humanization (Tabhu) a web server for antibody humanization.

Taking advantage of our experience in antibody sequence and structure analysis (Chailyan et al., 2011; Ghiotto et al., 2011; Marcatili et al., 2013), we developed Tools for AntiBody Humanization (Tabhu), a comprehensive platform meant to help antibody humanization experiments.

The approaching expiry of the exclusivity period of archetypal humanization patents [ 63- 66] provides an illustrative (but not comprehensive) rationale for the continued value of antibody humanization as an economical platform for drug development going forward.

This comparative analysis validates the design of bapineuzumab and attests to the robustness of antibody humanization technology as a platform for obtaining clinical development candidates from preclinical leads for disease therapy in humans.

The excellent agreement we report between the structures of 3D6 Aβ and that of 4HIX, as summarized in Table  2 and Figure  4, attests to the robustness and continued viability of antibody humanization as a rapid and efficient technology for lead optimization of biological drug candidates.

Supplementary Material, Supplementary File S1 reports an example of antibody humanization with Tabhu.

The benefit of performing antibody humanization was further evidenced by following the humanness and immunogenicity of therapeutic antibodies prior to and after humanization.

Our own antibody humanization efforts revealed that despite the high T20 scores for most donor human germline framework sequences, re-introducing specific parental framework sequences into a human germline sequence is sometimes sufficient to revert the T20 score of the humanized framework sequence to the same score as the initial parental framework sequence (Additional file 6: Figure S6).

In addition, the humanization work has sustained a significant research group at the MRC Collaborative Center Mill Hill, which offers a service to those companies wishing to contract out antibody humanization.