Sentence examples for for antibody diversification from inspiring English sources
Therefore, AID is haploinsufficient for antibody diversification and chromosome translocations.
Altogether these data indicate that AID is haploinsufficient for antibody diversification.
AID is specifically induced in germinal center B cells to carry out somatic hypermutation and class-switch recombination, which are two processes that are responsible for antibody diversification.
AID is a key enzyme for antibody diversification and due to its mutagenic activity outside immunoglobulin loci it is implicated in lymphomagenesis.
It is expressed in germinal center B cells and is essential for the events of class switch recombination and somatic hypermutation during the process of antibody diversification [ 26– 28].
The error-prone DNA repair of uracil residues is thought to be responsible for the generation of A/T mutations during antibody diversification in B cells by the activation-induced cytosine deaminase (AID) enzyme [19].
The requirement for CIB1 in AID-mediated processes was examined in two model systems for antibody gene diversification, the chicken B cell line DT40 and murine B lymphocytes.
The DNA cytosine deaminase activity of AID is essential for antibody gene diversification through the distinct processes of somatic hypermutation and class switch recombination [ 16].
We also uncover a potential mechanistic explanation for the targeting and off-target preferences of the antibody diversification mutator AID.
Neuberger, M. S. Antibody diversification by somatic mutation: from Burnet onwards.
Basu, U. et al. The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
