For this ancillary analysis, IPF medication was defined very comprehensively, as any of the following: prednisone, other steroid, azathioprine, cyclophosphamide, mycophenolate mofetil, NAC, pirfenidone, other drugs for IPF treatment, or prophylactic or therapeutic anticoagulation.
An ancillary analysis was conducted for this subgroup of patients.
The ancillary analysis that controlled for weight change during the study provides additional insight into the possible effects of elevated depression symptoms and ADM use on CVD risk factor status.
Writing a good SAP for a model-based sensitivity or ancillary analysis [ 1, 2] involves non-trivial decisions on and justification of many aspects of the chosen model setting.
As another ancillary analysis we checked for a possible delayed effect of lutein supplementation, under the hypothesis that the effect of lutein may only appear after six or twelve weeks.
Finally, we conclude with recommendations for ancillary benefits analysis and related research gaps in the relevant disciplines.
A non-significant improvement was found for endpoints, allocation concealment, baseline data, outcomes and estimation of effect, ancillary analysis, interpretation of results and overall evidence (Table 2).
Patients and methods: Ancillary analysis of data prospectively collected from 220 ICU communicative patients enrolled for the validation of the IC-RDOS.
These ancillary analyses, however, should be interpreted with caution; chi-square tests require that expected sample sizes for each cell be greater than five, an assumption that was violated in this ancillary analysis.
Because this is an ancillary analysis following on from a previously published study, 10 the power for this analysis was carried out based on weight loss.
