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Importantly, the study will serve as the backbone for ancillary analyses to meet additional vitamin D related research needs and for various other studies to harness the considerable potential of the parent study for obtaining new knowledge beyond its primary goals (www.d2dstudy.org/ancillarystudies).org/ancillarystudies
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We also conducted a series of ancillary analyses.
The decision on the models for sensitivity and ancillary analyses and handling of informative missing data of the large phase III BEMED trial is based on data from a pre-study with a comparable study population, comparable intervention, and same definition of primary outcome (frequency of vertigo attacks).
To account for that, we have performed ancillary analyses with models for HT and non-dipping risks testing HbA1c and duration of diabetes as dichotomous factors.
In general, the program was equally beneficial for all participants, but ancillary analyses indicated added benefits with respect to task value for students with relatively lower prior science achievement during the first year of college and with respect to subsequent science course taking for males.
We performed ancillary analyses for single infections with HPV 16 or 18, the genotypes that account for the majority of cervical cancer cases worldwide.
Therefore, these Bayesian model selection techniques offer helpful decision support for shaping sensitivity and ancillary analyses in a statistical analysis plan of a clinical trial with longitudinal count data as the primary endpoint.
To write a good SAP for model-based sensitivity and ancillary analyses involves non-trivial decisions on and justification of many aspects of the chosen setting.
The instruments under study provide excellent tools for preparing decisions within the SAP in a transparent way when structuring the primary analysis, sensitivity or ancillary analyses, and specific analyses for secondary endpoints.
In addition, we have examined the feasibility of obtaining sufficient high-quality tissue samples with EBUS-TBNA for ancillary molecular analyses which can provide additional diagnostic information for these patients.
In ancillary analyses, we used proximity of residence lived in for the longest time and proximity of most recent residence.
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