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The evaluable immunogenicity population for analysis of the primary objective included 207 patients (155 adults and 52 children); the most common reason for exclusion from this population was receipt of <3 doses of PCV13 in the sequence assigned.
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Major protocol deviations leading to exclusion from analysis of the primary objective were found in five patients.
The Reference Standard is the method that was prospectively identified in the clinical protocol as the method that would be used for the analysis of the primary objective.
The main analysis for the primary objective was based on the number of hours between infectious challenge and blood stage parasitaemia.
Formal sample size calculations were not applicable for assessment of the primary objective (safety/tolerability profile).
However to our knowledge no suitable non-parametric methods exist for non-inferiority analysis, which was the primary objective of the study.
Strobe 16: Please provide 95% confidence intervals for the estimated proportion of the primary objective.
The FGDs that serve as the data source for this analysis were conducted with the primary objective of orienting and adapting a primary care cardiovascular disease risk reduction intervention to San José, Costa Rica and Tuxtla Gutiérrez, Chiapas, México.
It concerns the representation of deductive reasoning, for many logicians the primary objective of logic.
Qualitative analysis of written responses in the questionnaires was undertaken with identification of themes emerging from data relating to reasons for therapeutic refusal being the primary objective of analysis.
These limitations minimize the modifications' implications for the factor structure the testing of which was the primary objective of this analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com