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Figure 1 is the inclusion and exclusion flowchart, which shows that 2,106 patients were available for analysis, composed of 35% from the CHUSJ database and 65% from the MCH database.

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Using the first five rounds of ESS data, we were able to obtain a large sample of natives for our analysis, composed of 143,375 observations from 26 countries.

The database for analysis was composed of 421,461 men and 90,141 women.

The final genotyping data for analysis were composed of 2 543 887 SNPs in HapMap using allele dosage (0 2) values.

The final sample for analysis is composed of 2,418 individuals (1,073 men and 1,345 women) for whom complete data for the variables of interest were available.

The electrophoretic buffer for µLAS analysis was composed of 1X Tris-Borate-EDTA (TBE, 89 mM Tris, 89 mM boric acid, 2 mM EDTA) supplemented with 1.3 MDa Polyvinylpyrrolidone (PVP) and Dithiothreitol (DTT) dissolved at 5% and 2% in weight, respectively, and YOPRO-1 at 100 nM for DNA fluorescent labelling.

Tissue microarrays suitable for IHC analysis were composed from a series of early stage breast cancer patients ('Oslo0/ULL').

The final set of proteins used for the analysis was composed of 109 sequences, with representatives of each PRDM member in all 7 species except for PRDM3 (missing in fugu), PRDM17 (missing in fugu and chicken), and the non-primate PRDM7/9 (missing in chicken and frog).

The sample for this secondary analysis was composed of the 24 Hispanic older adults with chronic osteoarthritis pain.

It is still formally possible, though less likely, that the cell populations used for this microarray analysis were composed of a heterogeneous mixture of cells with different aneuploidies that could have cancelled each other out (i.e. for every cell that gained a particular chromosome there could have been another cell that lost that same chromosome).

This is the case for the system under analysis here, composed by a network of particles which are very small compared to the overall volume.

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