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The in vitro release profile of RB for all formulations is shown in Fig. 10.
A moderate initial burst for all formulations; Faster drug release from the 50 50 copolymers; and.
The amount of WSF was fixed at 40 phr for all formulations.
The lysozyme activity was >94 ± 5% for all formulations exhibiting a full preservation of enzyme activity.
Good cytocompatibility for all formulations was observed after 1 h of incubation.
More than 52% of nano-structured coatings (for all formulations) were <200 nm in diameter.
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The zeta potential was positive (+22 to +42 mV) for all the formulations and was suitable for ophthalmic application.
For all the formulations tested, the viability for fibroblast was greater than 97%, indicating that PEG-D was noncytotoxic and that pH has no effect on its cytocompatibility.
For all the formulations tested, the storage modulus (G′) values were greater than the loss moduli (G ′′), indicating the hydrogels were chemically cross-linked.
For all these formulations the exposure for the consumer was estimated using the algorithms of the TGD with some modifications (limited to maximal possible concentration in air using ideal gas law and fugacity, limited to maximal amount used).
The n values for formulations F14 indicated Fickian-diffusion, whereas n values for all the other formulations denoted Super Case II (Table 7).
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