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Literature-based rates [ 84] for treatment-emergent diabetes were used as upper bounds for all comparators.
Resource consumption during the post-progressed stage (the same post-progression management was assumed for all comparators).
Evidence was also insufficient for assessment of optimal timing of initiation of pharmacoprophylaxis for all comparators and outcomes.
Utility decrements for the rest of the states were set equal for all comparators to avoid possible bias.
Finally, it is clear that the total cost related to anti-depressant treatment is mainly driven by the indirect cost for all comparators.
The overall incidence of mortality was 5 deaths among 745 patients (0.7%) for all HES cases and 8 deaths among 793 patients (1.0%) for all comparators.
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A subsequent analysis found that total healthcare expenditures were lower for aripiprazole than ziprasidone, olanzapine and risperidone, and mental health expenditures were lower for aripiprazole than all comparators [ 14].
41 The efficacy rates for all the comparators included can be seen in Table 1.
Figure 2 illustrates the decomposition of total cost for all branded comparators.
Compared to aripiprazole, total medical costs were higher for quetiapine but not significantly different for all other comparators.
Those with 'no complications' and 'bleeding' in stage 1 were assumed to move on to stage 2 for all the comparators.
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