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When adenoma were classified as advanced (larger than 9 mm, or with villous or tubulo-villous histological pattern (>20%), or with high-grade dysplasia) or not advanced, Hb content was significantly higher for advanced adenomas (N=669, average 550 ng ml−1, median 356 ng ml−1) as compared with not advanced ones (N=221, average 385 ng ml−1, median 222 ng ml−1).
Sensitivity appeared to be equally high for patients with node-negative and advanced disease, as well as for advanced adenomas.
Sensitivity for advanced adenomas was low (11.2%).
Moreover, test characteristics for advanced adenomas were not available.
As a model for advanced adenomas VACO235 were used.
Sensitivity of mSEPT9 for advanced adenomas was very low.
Similar(7)
Harboring an SSA/P was associated with a higher risk for advanced adenoma in the proximal compared with distal colon (advanced adenoma proximal (OR=8.05, 95% CI 1.8 79) and distal (OR= 2.8, 95% CI 2.05 29.5)).
Analyses of the effects of obesity on more clinically significant lesions demonstrated that high BMI was a slightly stronger risk factor for advanced adenoma recurrences in men (OR, 1.62; 95% CI, 1.04 2.53) when compared with non-advanced lesions (OR, 1.26; 95% CI, 0.91 1.75).
The positive predictive value of FIT was 39.5% for adenoma, 11.7% for advanced adenoma, and 6.1% for invasive cancers.
The ROC curves and AUC's for advanced adenoma were very similar between males and females (see Figure 3).
Simulation of multiple screening rounds indicated that sensitivity of FIT for advanced adenoma could reach 81% after 5 screening rounds.
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