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This phenomenon has not been appreciated in the previous mutagenesis experiments, indicating this might be a new clue for additional functional study of Kv1 channels.
DAVID Bioinformatics Resources (http://david.abcc.ncifcrf.gov) was also used for additional functional annotation [65].
In our search for additional functional motifs, we found that a class of bone marrow homing peptides BMHP [20] could be one of the most promising family candidates for stimulating NSC adhesion and differentiation.
Since we found significant cancer-related pathways associated only with BMPR1A but not with WDTC1 or EHD3, and in addition germline mutations in BMPR1A are a known risk factor for juvenile polyposis syndrome, we chose BMPR1A for additional functional assays (Figure 3, Figure S5).
Further investigation is required in the search for additional functional lncRNAs in NPC.
At the same time, HIA's predictions will allow the prioritization of variants for additional functional investigation.
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Moreover, the new design gives the possibility for simple introduction of additional functional modules such as: sensorized modules for non-geometrical orientation of parts, or active orientation modules for improving efficiency of the system.
Here we reveal the construction and use of this custom-made robot for the isolation of ultra-pure plasmid DNA for efficient transfections that can be used for many additional functional high-throughput screens.
As for an additional functional readout, preadipocytes transfected with a TLR4-specific siRNA showed significantly reduced IL-6 secretion upon stimulation with LPS compared to the controls.
Apart from the PER2-CBD-CRY2 complex, the crystal structures of CRY2 have been determined for four additional functional states, apo, FAD-, FBXL3-, and KL001-bound (Nangle et al., 2013; Xing et al., 2013).
We also analyzed the data for two additional functional classes reported to be enriched in positively selected genes in previous genome-wide studies: spermatogenesis and response to stimulus [ 23, 28, 35].
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