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A key consideration when developing any potential new antimicrobial strategy, particularly one based on a broad-spectrum agent, is its impact on resistance and whether modifying the existing microbiome creates niches for additional, emerging pathogens.
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Data analysis used pre-specified codes based on qualitative guides and research objectives and also followed a grounded theory approach, allowing for in-depth exploration of additional emerging themes in the participants' narrative responses [ 29].
Even though this work focused primarily on the application of high-content imaging techniques, and there are a number of inherent limitations to HCS or any other type of in vitro toxicity screening, the potential for combining HCS with additional emerging technologies such as quantitative genomics and metabolomics should be addressed in future studies.
Codes were also applied for additional themes emerging from the manuscript.
But in neither their private nor public meetings with Mr. Ridge did any requests for additional money emerge.
This also allowed for additional questions on emerging themes to be incorporated using a continuous validation process.
If the provider is willing to pay greater than $15,000 for additional QALY, ACEI emerged as the best intervention.
Notably, the researcher was careful not to be restricted by these pre-defined concepts, allowing for additional codes to emerge from the data inductively.
Evidence for additional roles might emerge on different genetic backgrounds, since lethality occurs earlier in another Ntn1 −/− strain (Bin et al., 2015).
When the provider is ready to pay any amount above $1,300 but not more than $15,000 for additional QALY, thiazide emerged as the best intervention.
In other cases, ideas for additional qualitative work emerged – for example, the relative absence of community-level research activities became apparent to the team - and the programme theory helped to frame this in the overall research programme.
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CEO of Professional Science Editing for Scientists @ prosciediting.com