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Important methodological issues, including the need for additional comparator datasets, the potential bias from missing data, and the impact of the "no improvement" rule, will need to be addressed and long term follow-up of all patients is essential to secure meaningful results.
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Third, the proposed equations ignore the potential for additional comparators to be introduced within the examined time horizon.
An additional comparator based logic that evaluates direction of micro-rotation within RICO reduces the data dependency between each iterations.
Additional comparators for the strategies including NITs were: (1) treat all patients with CHC irrespective of fibrosis; (2) treat none; and (3) biopsy all and treat those with fibrosis stage ≥F2.
For indirect and/or mixed-treatment comparison evidence, NICE considered additional comparators that PBAC did not, including rituximab, adalimumab, certolizumab, etanercept, and golimumab.
It also provides several comparators for additional research in the excluded countries.
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