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Profiles were randomly selected from these pools for a Bayesian analysis of actual study data coupled with partial simulated data for Cohort 1 patients whose complete data were not yet available and with future Cohort 2 data for the various dose/route combinations considered.
For DSM-IV diagnostics, mean overall kappa for the standard diagnosis of training videos was 0.77, and mean overall kappa for a randomly drawn subset of actual study patients was also 0.77 (95% CI 0.60 0.94).
For DSM-IV diagnostics mean overall kappa with training videos was 0.77, and mean overall kappa for a randomly drawn subset of actual study patients was also 0.77 (95% CI 0.60-0.94).
Of the 38 subjects in the pilot study, 10 (4 females and 6 males) fitted the criteria for the actual study (see below for derivation of criteria).
A set of 10 images, not included for the actual study, and a scripted instructional session were used for training purposes.
For the actual study, the task of participants was straightforward.
All mailings for the actual study were sent between March and October 2011.
The subjects underwent the entire sequence of examination and laboratory procedures as planned for the actual study.
The questionnaire, however, included detailed information showing that the Pharmaceutical Unit in the Department of Health in the county of Västra Götaland was responsible for handling the addresses of the doctors and the nurses while the researchers and the University of Gothenburg were responsible for the actual study.
However, due to possibly misleading results caused by differences in colony forming capacity rather than drug effects, clonogenic assay was not used for the actual study (see Figure 2S in Supplementary Information and protocol E in Materials and Methods, Section 2.9).
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