Sentence examples for for achieving selectivity from inspiring English sources
The phrase "for achieving selectivity" is correct and usable in written English.
It can be used in contexts where you are discussing methods, strategies, or processes aimed at obtaining a specific level of selectivity in a particular situation or system.
Example: "The new algorithm was designed for achieving selectivity in data filtering, ensuring that only the most relevant information is processed."
Alternatives: "to attain selectivity" or "for obtaining selectivity".
The clearest non-bottleneck mechanisms for achieving selectivity are competitions.
Competition based mechanisms for achieving selectivity come in at least two varieties: In a simple race mechanism each of the competitors independently completes a process that is comparable, along some dimension of variation, with the processes completed by the other competitors.
An alternative approach for achieving selectivity in kinase inhibitors is the development of antagonists that act allosterically at sites distant from the catalytic domain [20].
Overall, targeting kinase-substrate complexes may offer a general approach and new avenue for achieving selectivity for kinases with high structural similarity to other proteins.
PfCDPK1 therefore represents a novel target for the potential treatment of malaria and offers promise for achieving selectivity over the kinases of the human host.
PknB is an attractive target as the kinase domain contains less than 30% similarity with eukaryotic kinases, which offers promise for achieving selectivity for the mycobacterial kinase over those of the human host.
Eventually, the challenge of achieving selectivity for HKs among the GHKL proteins will need to be addressed.
With respect to achieving selectivity for APHs vs. ePKs, the three kinase-CKI-7 structures reveal ample differences in binding, as also reflected in the variance in the enzymes' Ki values, to confidently suggest that inhibitors based on the isoquinoline scaffold can be developed for either APH(3' -IIIa or APH(9)-Ia that do not bind to CK1 and likely other ePKs.
However, GSK-J4 has also been reported to inhibit the KDM5 subfamily in vitro (~ 20-fold less active relative to KDM6 inhibition) further highlighting the difficulties in achieving selectivity for this class of enzymes.
However, the greatest challenge for ATP-competitive inhibitors is achieving selectivity versus other kinases, including the closely related insulin receptor (IR) which shares high overall sequence homology and complete homology among the residues that contact ATP in the kinase-binding domain.
A major challenge, however, is achieving selectivity.
