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Additionally, there are issues relating to optimal antigenic target identification, criteria for acceptable efficacy, identification of the target population in children as well as adults, commercial development limitations, optimal timing of immunization strategy, storage and cold chain requirements, cost of development and cost effectiveness (64).
In order to provide an effective vaccine against S. aureus, a number of unresolved issues in vaccine development relating to optimal antigenic target identification, criteria for acceptable efficacy, identification of target population, commercial development limitations, optimal timing of immunization strategy, storage, cold chain requirements and cost need to be addressed properly.
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However, in recent years, colistin was observed to be probably less toxic than previously proposed, and to offer an acceptable efficacy for treatment of severe infections due to MDR gram-negative bacteria [ 2].
Finally, in scenario 5, all doses are safe but none have acceptable efficacy and the correct decision is to terminate for futility.
However, to allow for dosing variations when using a fixed dose combination and the inter-subject pharmacokinetic variability seen with artesunate, the decision matrix selected the dose above that which showed, on average, acceptable efficacy.
Educational interventions showed an acceptable efficacy.
CBA has an acceptable efficacy profile in real practice.
Additional work is needed in this area to define agro-ecosystems where dry soil may be solarized with acceptable efficacy.
Salvage prostate cryotherapy is a viable option with an acceptable efficacy and toxicity profile.
Salvage prostate cryoablation (SPC) has an acceptable efficacy and toxicity profile (Ahmad et al, 2013).
Other than the standard criteria for acceptable safety and efficacy, and desirable pharmaceutical characteristics (e.g., stability, ease of administration, etc).
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